miR-30 Family Reduction Maintains Self-Renewal and Promotes Tumorigenesis in NSCLC-Initiating Cells by Targeting Oncogene TM4SF1.

@article{Ma2018miR30FR,
  title={miR-30 Family Reduction Maintains Self-Renewal and Promotes Tumorigenesis in NSCLC-Initiating Cells by Targeting Oncogene TM4SF1.},
  author={Yushui Ma and Fei Yu and Xiaoming Zhong and Gaixia Lu and Xianling Cong and Shao-Bo Xue and Wenting Xie and Likun Hou and Lijuan Pang and Wei Wu and Wei Zhang and Lele Cong and Tie Liu and Huideng Long and Ran Sun and Hongwen Sun and Zhongwei Lv and Chun-yan Wu and Da Fu},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2018},
  volume={26 12},
  pages={
          2751-2765
        }
}
  • Yushui Ma, Fei Yu, D. Fu
  • Published 1 December 2018
  • Biology, Chemistry
  • Molecular therapy : the journal of the American Society of Gene Therapy
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References

SHOWING 1-10 OF 52 REFERENCES
Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells
TLDR
The data suggest mir-30 as one of the important miRNAs in regulating the stem-like features of T-ICs, which have a pivotal role in tumorigenesis, tumor progression, metastasis and post-treatment relapse.
microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18
TLDR
It is demonstrated that miR-30b/c was down-regulated in NSCLC specimens compared with adjacent non-tumor tissues and could serve as a tumor suppressor gene involved inNSCLC pathogenesis.
High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1
TLDR
The results provide the first evidence that NCOA1 is a direct target of miR-105-1 suggesting that N COA1 andmiR- 105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC patients.
Low expression of microRNA-30c promotes invasion by inducing epithelial mesenchymal transition in non-small cell lung cancer.
TLDR
Qualitative polymerase chain reaction demonstrated that the expression of miR‑30c was reduced in lung cancer specimens and regulated the invasion of NSCLC cells and low miR-30 levels induced EMT.
MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1
TLDR
The essential role of miR-26a/Jagged1/Notch pathway in regulating the stem cell-like traits of osteosarcoma cells and provide a potential target for osteosARcoma therapy are suggested.
High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1
TLDR
ITGB1 and miR-493-5p may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of NSCLC patients and provide the first evidence that ITGB1 is a direct target of miR -493- 5p.
miR-30 family promotes migratory and invasive abilities in CD133+ pancreatic cancer stem-like cells
TLDR
It is demonstrated that high expression of the miR-30 family modulated by CD133 promotes migratory and invasive abilities in CD133+ pancreatic cancer cells, suggesting that targeted therapies to the miRNAs contribute to the development of novel therapies for CD133+.
MicroRNA-30a-5p Inhibits the Growth of Renal Cell Carcinoma by Modulating GRP78 Expression
TLDR
MiR-30a-5p is a bona fide negative regulator of GRP78 expression, and the anti-tumor activity of miR- 30a- 5p in ccRCC is due at least in part to down-regulating GRP 78 expression and modulating the unfolded protein response (UPR) pathway.
miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT
TLDR
The finding reveals a new post-transcriptional mechanism of TMPRSS2-ERG regulation by Src and growth signals via miR-30 providing a rationale for targeting ERG-positive castration-resistant tumors with Src inhibitors.
...
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