miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells.

@article{Amodio2013miR29bIS,
  title={miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells.},
  author={Nicola Amodio and Dina Bellizzi and Marzia Leotta and Lavinia Raimondi and Lavinia Biamonte and Patrizia D'Aquila and Maria Teresa Di Martino and Teresa Calimeri and Marco Rossi and Marta Lionetti and E. Austin Leone and Giuseppe Passarino and Antonino Neri and Antonio Giordano and Pierosandro Tagliaferri and Pierfrancesco Tassone},
  journal={Cell cycle},
  year={2013},
  volume={12 23},
  pages={
          3650-62
        }
}
Epigenetic silencing of tumor suppressor genes frequently occurs and may account for their inactivation in cancer cells. We previously demonstrated that miR-29b is a tumor suppressor microRNA (miRNA) that targets de novo DNA methyltransferases and reduces the global DNA methylation of multiple myeloma (MM) cells. Here, we provide evidence that epigenetic activity of miR-29b leads to promoter demethylation of suppressor of cytokine signaling-1 (SOCS-1), a hypermethylated tumor suppressor gene… CONTINUE READING

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