miR-296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma.

Abstract

MiR-296 was previously reported to be underexpressed in hepatocellular carcinoma (HCC). However, the clinical value of miR-296 and its function in HCC remain poorly understood. In this study, we found that miR-296 levels are decreased in HCC specimens and cells, and that the underexpression of miR-296 is associated with adverse clinical parameters and poor overall survival rate. In vitro experiments indicate that miR-296 inhibits proliferation, colony formation, and cell cycle progression, and enhances apoptosis in HCC cells. Notably, we found that the fibroblast growth factor receptor 1 (FGFR1) is a downstream target that mediates the functions of miR-296 in HCC. Thus, our findings indicate that miR-296 exerts a tumor suppressive role in HCC and is a potential biomarker and drug-target.

DOI: 10.1002/1873-3468.12442

Cite this paper

@article{Wang2016miR296IP, title={miR-296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma.}, author={Liyan Wang and Xiaotong Bo and Qinghua Zheng and Xuhua Xiao and Linling Wu and Bin Li}, journal={FEBS letters}, year={2016}, volume={590 23}, pages={4252-4262} }