miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling.

@article{Kapinas2009miR29SO,
  title={miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling.},
  author={Kristina Kapinas and Catherine B. Kessler and Anne M. Delany},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={108 1},
  pages={216-24}
}
The matricellular protein osteonectin, secreted protein acidic and rich in cysteine (SPARC, BM-40), is the most abundant non-collagenous matrix protein in bone. Matricellular proteins play a fundamental role in the skeleton as regulators of bone remodeling. In the skeleton, osteonectin is essential for the maintenance of bone mass and for balancing bone formation and resorption in response to parathyroid hormone (PTH). It promotes osteoblast differentiation and cell survival. Mechanisms… CONTINUE READING
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