miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion

Abstract

T cell exhaustion is a state of T cell dysfunction that arises during many cancer. miRNAs are one of major gene regulators which result in translational inhibition and/or mRNA degradation. We hypothesized that miRNAs exist that can silence PD1 and act as a modulator in vitro to revert exhaustive status of T cells. We demonstrated that the exhausted T cells… (More)
DOI: 10.18632/oncotarget.10731

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Cite this paper

@inproceedings{Li2016miR28ME, title={miR-28 modulates exhaustive differentiation of T cells through silencing programmed cell death-1 and regulating cytokine secretion}, author={Qing Li and Nathan Johnston and Xiufen Zheng and Hongmei Wang and Xusheng Zhang and Dian Shuai Gao and Wei-ping Min}, booktitle={Oncotarget}, year={2016} }