miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.

@article{Lin2010miR24UI,
  title={miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.},
  author={Shu-Chun Lin and Chung-Ji Liu and Jung-An Lin and W F Chiang and Pei-Shih Hung and Kuo-Wei Chang},
  journal={Oral oncology},
  year={2010},
  volume={46 3},
  pages={204-8}
}
MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking… CONTINUE READING

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