miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.

@article{Lal2009miR24IC,
  title={miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.},
  author={Ashish Nandan Lal and Francisco F Navarro and Christopher A. Maher and Laura E Maliszewski and Nan Yan and Elizabeth Tucker O'Day and Dipanjan Chowdhury and Derek Michael Dykxhoorn and Perry Tsai and Oliver Hofmann and Kevin G. Becker and Myriam Gorospe and Winston A Hide and Judy Lieberman},
  journal={Molecular cell},
  year={2009},
  volume={35 5},
  pages={610-25}
}
miR-24, upregulated during terminal differentiation of multiple lineages, inhibits cell-cycle progression. Antagonizing miR-24 restores postmitotic cell proliferation and enhances fibroblast proliferation, whereas overexpressing miR-24 increases the G1 compartment. The 248 mRNAs downregulated upon miR-24 overexpression are highly enriched for DNA repair and cell-cycle regulatory genes that form a direct interaction network with prominent nodes at genes that enhance (MYC, E2F2, CCNB1, and CDC2… CONTINUE READING

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The 248 mRNAs downregulated upon miR-24 overexpression are highly enriched for DNA repair and cell - cycle regulatory genes that form a direct interaction network with prominent nodes at genes that enhance ( MYC , E2F2 , CCNB1 , and CDC2 ) or inhibit ( p27Kip1 and VHL ) cell - cycle progression .
Genes, RegulatorGene encodes gene productCyclin B1
The 248 mRNAs downregulated upon miR-24 overexpression are highly enriched for DNA repair and cell - cycle regulatory genes that form a direct interaction network with prominent nodes at genes that enhance ( MYC , E2F2 , CCNB1 , and CDC2 ) or inhibit ( p27Kip1 and VHL ) cell - cycle progression .
Proto-Oncogene Proteins c-mycGene product plays role in biological processCell Proliferation
Enhanced proliferation from antagonizing miR-24 is abrogated by knocking down E2F2 , but not MYC , and cell proliferation , inhibited by miR-24 overexpression , is rescued by miR-24-insensitive E2F2 .
miR-24 Inhibits cell proliferation by targeting E2F2 , MYC , and other cell - cycle genes via binding to " seedless " 3'UTR microRNA recognition elements .
Antagonizing miR-24 restores postmitotic cell proliferation and enhances fibroblast proliferation , whereas overexpressing miR-24 increases the G1 compartment .
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