miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1

@inproceedings{Gindin2015miR23aIB,
  title={miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1},
  author={Yevgeniy Gindin and Yuan Ying Jiang and Princy Francis and Robert Lee Walker and Ogan Demir Abaan and Yuelin Jack Zhu and Paul S. Meltzer},
  booktitle={Front. Genet.},
  year={2015}
}
Osteosarcoma is the most common type of bone cancer in children and adolescents. Impaired differentiation of osteoblast cells is a distinguishing feature of this aggressive disease. As improvements in survival outcomes have largely plateaued, better understanding of the bone differentiation program may provide new treatment approaches. The miRNA cluster miR-23a~27a~24-2, particularly miR-23a, has been shown to interact with genes important for bone development. However, global changes in gene… CONTINUE READING
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