miR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis

@article{Musto2015miR23aMA,
  title={miR-23a, miR-24 and miR-27a protect differentiating ESCs from BMP4-induced apoptosis},
  author={Anna Musto and Angelica Navarra and A Vocca and Adriana Gargiulo and Giuseppina Minopoli and Simona Romano and Maria Fiammetta Romano and Tommaso Russo and Silvia Parisi},
  journal={Cell Death and Differentiation},
  year={2015},
  volume={22},
  pages={1047-1057}
}
Numerous studies have indicated that BMP4 signaling is involved in the regulation of the early steps of development. In mouse embryonic stem cells (ESCs), BMP4 is crucial to sustain pluripotency and blocks differentiation towards neural fate. Here, through a systematic analysis of miRNAs in ESCs, we establish that BMP4 signaling regulates miR-23a, 27a and 24-2, through the recruitment of phospho-Smads at the promoter of the gene encoding this miRNA cluster. Suppression of miR-23a/b, 27a/b and… CONTINUE READING
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