miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination.

@article{Lin2009miR23RO,
  title={miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination.},
  author={Shu-Ting Lin and Ying-Hui Fu},
  journal={Disease models & mechanisms},
  year={2009},
  volume={2 3-4},
  pages={
          178-88
        }
}
Duplication of the gene encoding lamin B1 (LMNB1) with increased mRNA and protein levels has been shown to cause severe myelin loss in the brains of adult-onset autosomal dominant leukodystrophy patients. Similar to many neurodegenerative disorders, patients with adult-onset autosomal dominant leukodystrophy are phenotypically normal until adulthood and the defect is specific to the central nervous system despite the ubiquitous expression pattern of lamin B1. We set out to dissect the molecular… CONTINUE READING

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