miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway.

@article{Han2016miR223RT,
  title={miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway.},
  author={Jing Han and Fengyi Zhao and Jing Zhang and Hua Zhu and Hu Gen Ma and Xuetao Li and Lina Peng and Jianguo Sun and Zhengtang Chen},
  journal={International journal of oncology},
  year={2016},
  volume={48 5},
  pages={
          1855-67
        }
}
Acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, is a critical issue for the treatment of EGFR mutant-positive non-small cell lung cancer (NSCLC). Recent evidence supports the role of microRNA-223 (miR‑223) in modulating chemotherapeutic drug sensitivity, but its role in the resistance to EGFR-TKIs in NSCLC remains unclear. To this end, we investigated the involvement of miR‑223 in erlotinib resistance, using two… CONTINUE READING

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