miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2

@inproceedings{Nian2013miR223FA,
  title={miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2},
  author={Weiqi Nian and Xujun Ao and Yongzhong Wu and Yi Huang and Jianghe Shao and Yiming Wang and Zhengtang Chen and Fanglin Chen and Donglin Wang},
  booktitle={Oncology letters},
  year={2013}
}
microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains limited. In the current study, miR-223 was found to inhibit cell proliferation in vitro by CCK-8 assay, growth curves and an anchorage-independent growth assay in a Lewis lung… CONTINUE READING

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