miR-221 is required for endothelial tip cell behaviors during vascular development.

  title={miR-221 is required for endothelial tip cell behaviors during vascular development.},
  author={Stefania Nicoli and Carl-Philipp Knyphausen and Lihua Julie Zhu and Abirami Lakshmanan and Nathan D. Lawson},
  journal={Developmental cell},
  volume={22 2},
Angiogenesis requires coordination of distinct cell behaviors between tip and stalk cells. Although this process is governed by regulatory interactions between the vascular endothelial growth factor (Vegf) and Notch signaling pathways, little is known about the potential role of microRNAs. Through deep sequencing and functional screening in zebrafish, we find that miR-221 is essential for angiogenesis. miR-221 knockdown phenocopied defects associated with loss of the tip cell-expressed Flt4… CONTINUE READING
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