miR-221 Mediates Chemoresistance of Esophageal Adenocarcinoma by Direct Targeting of DKK2 Expression.

  title={miR-221 Mediates Chemoresistance of Esophageal Adenocarcinoma by Direct Targeting of DKK2 Expression.},
  author={Yanli Wang and Yue Zhao and Andreas Herbst and Thomas Kalinski and Jiwei Qin and Xiaoyan Wang and Zhenzhong Jiang and Frank Benedix and Sabine Franke and Thomas Wartman and Peter Camaj and Walter Halangk and Frank Thomas Kolligs and Karl Walter Jauch and Peter Jon Nelson and Christiane J Bruns},
  journal={Annals of surgery},
  volume={264 5},
BACKGROUND Chemoresistance is a main obstacle to effective esophageal cancer (EC) therapy. We hypothesize that altered expression of microRNAs (miRNAs) play a role in EC cancer progression and resistance to 5-fluorouracil (5-FU) based chemotherapeutic strategies. METHODS Four pairs of esophageal adenocarcinoma (EAC) cell lines and corresponding 5-FU resistant variants were established. The expression levels of miRNAs previously shown to be involved in the general regulation of stem cell… CONTINUE READING
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