miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.

  title={miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.},
  author={Junxia Zhang and Lei Han and Youlin Ge and Xuan Zhou and Anling Zhang and Chunzhi Zhang and Yue Zhong and Yongping You and Peiyu Pu and Chunsheng Kang},
  journal={International journal of oncology},
  volume={36 4},
MicroRNAs (miRNAs) are short regulatory RNAs that negatively modulate protein expression at a post-transcriptional level. Emerging evidence suggests that miRNAs play important roles in the pathogenesis of several types of cancers. However, the further mechanisms of miRNA remain unknown. In this study, we aimed to explore the coordinated function of miR-221/222 in glioma by bioinformatics and experiment methods. Bioinformatics analysis revealed that miR-221/222 had the potential to regulate… CONTINUE READING
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