miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation.

@article{Li2017miR221222PC,
  title={miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation.},
  author={Bailong Li and Ying Lu and Lihui Yu and Xiaocui Han and Hong-Hai Wang and Jun Mao and Jie Shen and Bo Wang and Jianwu Tang and Chun-yan Li and Bo Geun Song},
  journal={Chemico-biological interactions},
  year={2017},
  volume={277},
  pages={33-42}
}
MicroRNAs (miRNAs) play an important role in regulating cancer stem cell (CSC). Previous studies have shown that microRNA-221/222 (miR-221/222) cluster are involved in the propagation of breast cancer stem cell (BCSC), however, the underlying molecular mechanisms are still not fully understood. In this study, we found that miR-221/222 were overexpressed in highly aggressive breast cancer MDA-MB-231 cells, that are enriched in markers for epithelial-mesenchymal transition (EMT) and BCSCs, than… CONTINUE READING

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