miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.

@article{Garofalo2009miR221222RT,
  title={miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.},
  author={Michela Garofalo and Gianpiero di Leva and Giulia Romano and Gerard J Nuovo and Sung-Suk Suh and Apollinaire Ngankeu and Cristian Taccioli and Flavia Pichiorri and H. B. John Alder and Paola Secchiero and Pierluigi Gasparini and Arianna Gonelli and Stefan Costinean and Mario Acunzo and Gerolama Condorelli and Carlo M. Croce},
  journal={Cancer cell},
  year={2009},
  volume={16 6},
  pages={
          498-509
        }
}
Lung and liver cancers are among the most deadly types of cancer. Despite improvements in treatment over the past few decades, patient survival remains poor, underlining the need for development of targeted therapies. MicroRNAs represent a class of small RNAs frequently deregulated in human malignancies. We now report that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells. We show… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 384 CITATIONS, ESTIMATED 45% COVERAGE

Autophagy and thyroid carcinogenesis: genetic and epigenetic links.

  • Endocrine-related cancer
  • 2013
VIEW 16 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

MiR-221/222 promote epithelial-mesenchymal transition by targeting Notch3 in breast cancer cell lines

  • npj Breast Cancer
  • 2018
VIEW 7 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells

  • Cancer medicine
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Non-coding RNAs in lung cancer

  • Oncoscience
  • 2014
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 38 Highly Influenced Citations

  • Averaged 35 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

What Goes Up Must Come Down

VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

A regulatory ‘‘miRcircuitry’’ involving miR-221&222 and ER-a determines ER-a status of breast cancer cells

G. Di Leva, P. Gasparini, +7 authors H Alder
  • J. Natl. Cancer Inst. in press
  • 2009
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…