miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer.

@article{Tatarano2011miR218OT,
  title={miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer.},
  author={Shuichi Tatarano and Takeshi Chiyomaru and Kazumori Kawakami and Hideki Enokida and Hirofumi Yoshino and Hideo Hidaka and Takeshi Yamasaki and Kazuya Kawahara and Kenryu Nishiyama and Naohiko Seki and Masayuki Nakagawa},
  journal={International journal of oncology},
  year={2011},
  volume={39 1},
  pages={13-21}
}
Growing evidence suggests that microRNAs (miRNAs) are aberrantly expressed in many human cancers, and that they play significant roles in carcinogenesis and cancer progression. The identification of tumor suppressive miRNAs and their target genes could provide new insights into the mechanism of carcinogenesis. However, the genetic or epigenetic regulations of these miRNAs have not yet been fully elucidated in bladder cancer (BC). Chromosomal alterations of cancer cells give us important… CONTINUE READING