miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma.

@article{Luo2018miR216bET,
  title={miR-216b enhances the efficacy of vemurafenib by targeting Beclin-1, UVRAG and ATG5 in melanoma.},
  author={Meiying Luo and Longfei Wu and Kexin Zhang and Hong Hong Wang and Sharon K. Wu and Douglas O'Connell and Tongtong Gao and Hanbing Zhong and Yongfei Yang},
  journal={Cellular signalling},
  year={2018},
  volume={42},
  pages={
          30-43
        }
}
Autophagy maintains cells survival in many stressful conditions including starvation, growth factor deprivation and misfolded protein accumulation. Additionally, autophagic survival mechanisms are used by transformed tumor cells to inhibit cell death, limit drug effectiveness and possibly generate drug resistance. However, the mechanism of how cells utilize autophagy during drug resistance is not fully understood. Here, we demonstrate that miR-216b plays an important role in alleviating drug… CONTINUE READING
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