miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer.

@article{Wada2010miR212ID,
  title={miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer.},
  author={Rie Wada and Yoshimitsu Akiyama and Yutaka Hashimoto and Hiroshi Fukamachi and Yasuhito Yuasa},
  journal={International journal of cancer},
  year={2010},
  volume={127 5},
  pages={1106-14}
}
To clarify the role of micro (mi) RNAs in gastric carcinogenesis, we studied the expression and function of miRNAs in gastric carcinoma (GC) cells. Initially, we performed microarray analysis using total RNA from 3 human GC cell lines and noncancerous gastric tissue. Among the downregulated miRNAs in GC cells, miR-212 expression was decreased in all 8 GC cell lines examined and a significant decrease of miR-212 expression in human primary GC tissues was also observed in 6 of 11 cases… CONTINUE READING

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