miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis

@inproceedings{McCormick2013miR210IA,
  title={miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis},
  author={Ross I McCormick and Christopher Blick and Jiannis Ragoussis and Johannes Sch{\"o}del and David R Mole and Atalie C Young and Peter John Selby and Rosamonde E. Banks and Adrian L. Harris},
  booktitle={British Journal of Cancer},
  year={2013}
}
Background:Clear cell renal cancer frequently harbours von Hippel–Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours.Methods:RCC4 and 786-O renal cancer cell lines transfected with either an empty vector or functional VHL and incubated in normoxia or hypoxia were examined for miR-210 expression… CONTINUE READING