miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.

@article{Zhang2015miR21IR,
  title={miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.},
  author={Jing Zhang and Jingjing Jiao and Silvia Cermelli and Kyle Muir and Kwang Hwa Jung and Ruhai Zou and A Rashid and Mihai Gagea and Sonya D Zabludoff and Raghu Kalluri and Laura Beretta},
  journal={Cancer research},
  year={2015},
  volume={75 9},
  pages={1859-67}
}
miR-21 is upregulated in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, where it is associated with poor prognosis. Here, we offer preclinical evidence that miR-21 offers a therapeutic and chemopreventive target in these liver cancers. In mice with hepatic deletion of Pten, anti-miR-21 treatment reduced liver tumor growth and prevented tumor development. These effects were accompanied with a decrease in liver fibrosis and a concomitant reduction of CD24(+) liver progenitor cells… CONTINUE READING
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