miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells.

@article{Pennati2014miR205IT,
  title={miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells.},
  author={Marzia Pennati and Alessia Lopergolo and Valentina Profumo and Michelandrea de Cesare and Stefania Sbarra and R. Valdagni and Nadia Zaffaroni and Paolo Gandellini and Marco Folini},
  journal={Biochemical pharmacology},
  year={2014},
  volume={87 4},
  pages={579-97}
}
Compelling evidence suggests that epithelial-to-mesenchymal transition is involved in the resistance of human cancer cells to chemotherapy. We previously reported that the expression of miR-205, a miRNA down-regulated in prostate cancer, is further repressed in prostate cancer cells undergoing epithelial-to-mesenchymal transition, suggesting a possible involvement of the miRNA in the acquisition of the chemoresistant phenotype. In the present study, we show that miR-205 replacement in… CONTINUE READING