miR-203 represses ‘stemness’ by repressing ΔNp63

  title={miR-203 represses ‘stemness’ by repressing ΔNp63},
  author={Anna Maria Lena and Ruby Shalom-Feuerstein and Pia Rivetti di Val Cervo and Daniel Aberdam and Richard A Knight and Gerry Melino and Eleonora Candi},
  journal={Cell Death and Differentiation},
The epidermis, the outer layer of the skin composed of keratinocytes, is a stratified epithelium that functions as a barrier to protect the organism from dehydration and external insults. The epidermis develops depending on the transcription factor p63, a member of the p53 family of transcription factors. p63 is strongly expressed in the innermost basal layer where epithelial cells with high clonogenic and proliferative capacity reside. Deletion of p63 in mice results in a dramatic loss of all… CONTINUE READING
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in stratified epithelia

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