miR-200b suppresses cell growth, migration and invasion by targeting Notch1 in nasopharyngeal carcinoma.

@article{Yang2013miR200bSC,
  title={miR-200b suppresses cell growth, migration and invasion by targeting Notch1 in nasopharyngeal carcinoma.},
  author={Xu Yang and Weichun Ni and Ke Lei},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2013},
  volume={32 5},
  pages={1288-98}
}
BACKGROUND/AIMS MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that play important roles in carcinogenesis and tumor progression. We investigated the roles and mechanisms of miR-200b in human nasopharyngeal carcinoma (NPC). METHODS We used quantitative real-time polymerase chain reaction (qRT-PCR) analyses to measure levels of miR-200b and Notch1 in NPC specimens and cell lines. Human NPC cell lines stably expressing miR-200b or control were used to analyze the tumour… CONTINUE READING

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