miR-200b inhibits CD133+ glioma cells by targeting the AKT pathway

  title={miR-200b inhibits CD133+ glioma cells by targeting the AKT pathway},
  author={Aiqun Liu and Qingyun Yu and Zhongxing Peng and Yeqing Huang and Shengpeng Diao and Jing Cheng and Wentao Wang and Ming-fan Hong},
  booktitle={Oncology letters},
MicroRNA-200b (miR-200b) is a tumor suppressor in multiple tumor types, including gastric cancer, breast cancer, ovarian cancer and glioma. The biological significance of a known normal and cancer stem cell marker, CD133, remains elusive. The aim of the present study was to identify the function and mechinism of miR-200b in suppressing CD133+ glioma cells. CD133+ glioma cells were sorted by flow cytometry. The expression of miR-200b, Ki67, GAP43, GFAP and CD133 were tested by reverse… CONTINUE READING
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