miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis

  title={miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis},
  author={Shigeyoshi Oba and Shintaro Kumano and Etsu Suzuki and Hiroaki Nishimatsu and Masao Takahashi and Hajime Takamori and Masatoshi Kasuya and Yousuke Ogawa and Kenichiro Sato and Kenjiro Kimura and Yukio Homma and Yasunobu Hirata and Toshiro Fujita},
  booktitle={PloS one},
Members of the miR-200 family of micro RNAs (miRNAs) have been shown to inhibit epithelial-mesenchymal transition (EMT). EMT of tubular epithelial cells is the mechanism by which renal fibroblasts are generated. Here we show that miR-200 family members inhibit transforming growth factor-beta (TGF-beta)-induced EMT of tubular cells. Unilateral ureter obstruction (UUO) is a common model of EMT of tubular cells and subsequent tubulointerstitial fibrosis. In order to examine the role of miR-200… CONTINUE READING
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