miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells.

@article{Eades2011miR200aRS,
  title={miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells.},
  author={Gabriel L Eades and Yuan Yao and Muhua Yang and Yongshu Zhang and Saranya Chumsri and Qun Zhou},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 29},
  pages={25992-6002}
}
Evidence supports a critical role for microRNAs (miRNAs) in regulation of tissue-specific differentiation and development. Signifying a disruption of these programs, expression profiling has revealed extensive miRNA dysregulation in tumors compared with healthy tissue. The miR-200 family has been established as a key regulator of epithelial phenotype and, as such, is deeply involved in epithelial to mesenchymal transition (EMT) processes in breast cancer. However, the effects of the miR-200… CONTINUE READING
117 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 117 extracted citations

Similar Papers

Loading similar papers…