miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression

@inproceedings{Wang2011miR200aPR,
  title={miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression},
  author={Bo Wang and Philip J W Koh and Catherine E. Winbanks and Melinda T. Coughlan and Aaron McClelland and Anna M.D. Watson and Karin Jandeleit-Dahm and Wendy C. Burns and Merlin C Thomas and Mark Emmanuel Cooper and Phillip Kantharidis},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic mediators, TGF-β1 and TGF-β2. RESEARCH DESIGN AND METHODS Rat proximal-tubular epithelial cells (NRK52E) were treated with TGF-β1 and TGF-β2 for 3 days, and expression of markers of epithelial-to-mesenchymal transition (EMT) and fibrogenesis were assessed by RT-PCR and Western… CONTINUE READING
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