miR-200a-5p regulates myocardial necroptosis induced by Se deficiency via targeting RNF11

  title={miR-200a-5p regulates myocardial necroptosis induced by Se deficiency via targeting RNF11},
  author={T. Yang and Changyu Cao and J. Yang and T. Liu and X. Lei and Z. Zhang and Shiwen Xu},
  journal={Redox Biology},
  pages={159 - 169}
  • T. Yang, Changyu Cao, +4 authors Shiwen Xu
  • Published 2018
  • Medicine, Biology
  • Redox Biology
  • Necroptosis has been discovered as a new paradigm of cell death and may play a key role in heart disease and selenium (Se) deficiency. Hence, we detected the specific microRNA (miRNA) in response to Se-deficient heart using microRNAome analysis. For high-throughput sequencing using Se-deficient chicken cardiac tissue, we selected miR-200a-5p and its target gene ring finger protein 11 (RNF11) based on differential expression in cardiac tissue and confirmed the relationship between miR-200a-5p… CONTINUE READING


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