miR-200-containing extracellular vesicles promote breast cancer cell metastasis.

  title={miR-200-containing extracellular vesicles promote breast cancer cell metastasis.},
  author={Minh Tuong Le and P{\'e}ter Hamar and Changying Guo and Emre Başar and Ricardo Perdig{\~a}o-Henriques and Leonora Balaj and Judy Lieberman},
  journal={The Journal of clinical investigation},
  volume={124 12},
Metastasis is associated with poor prognosis in breast cancer patients. Not all cancer cells within a tumor are capable of metastasizing. The microRNA-200 (miR-200) family, which regulates the mesenchymal-to-epithelial transition, is enriched in the serum of patients with metastatic cancers. Ectopic expression of miR-200 can confer metastatic ability to poorly metastatic tumor cells in some settings. Here, we investigated whether metastatic capability could be transferred between metastatic and… CONTINUE READING