miR-192 Directly Binds and Regulates Dicer1 Expression in Neuroblastoma

  title={miR-192 Directly Binds and Regulates Dicer1 Expression in Neuroblastoma},
  author={Galina Feinberg-Gorenshtein and Avital Guedj and Keren Shichrur and Marta Jeison and Drorit Luria and Yona Kodman and Shifra Ash and Meora Feinmesser and Liat Edry and Noam Shomron and Abraham Weizman and Isaac Yaniv and Smadar Avigad},
  booktitle={PloS one},
Neuroblastoma (NB) arises from the embryonic neural crest and is the most common extracranial solid tumor in children under 5 years of age. Reduced expression of Dicer1 has recently been shown to be in correlation with poor prognosis in NB patients. This study aimed to investigate the mechanisms that could lead to the down-regulation of Dicer1 in neuroblastoma. We used computational prediction to identify potential miRs down-regulating Dicer1 in neuroblastoma. One of the miRs that were… CONTINUE READING
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