miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis

@article{Lee2008miR19MA,
  title={miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis},
  author={Yoontae Lee and Rodney C Samaco and Jennifer R. Gatchel and Christina Thaller and Harry T. Orr and Huda Y. Zoghbi},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={1137-1139}
}
Spinocerebellar ataxia type 1 is caused by expansion of a translated CAG repeat in ataxin1 (ATXN1). The level of the polyglutamine-expanded protein is one of the factors that contributes to disease severity. Here we found that miR-19, miR-101 and miR-130 co-regulate ataxin1 levels and that their inhibition enhanced the cytotoxicity of polyglutamine-expanded ATXN1 in human cells. We provide a new candidate mechanism for modulating the pathogenesis of neurodegenerative diseases sensitive to… CONTINUE READING

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References

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Nature Neuroscience Volume

J Lim
Nature 452, • 2008

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