miR-185 Inhibits Fibrogenic Activation of Hepatic Stellate Cells and Prevents Liver Fibrosis

@inproceedings{Zhou2018miR185IF,
  title={miR-185 Inhibits Fibrogenic Activation of Hepatic Stellate Cells and Prevents Liver Fibrosis},
  author={Li Zhou and Shunai Liu and Ming Hua Han and Yanhua Ma and Shenghu Feng and Jing Zhao and Hongping Lu and Xiaoxue Yuan and Jun Cheng},
  booktitle={Molecular therapy. Nucleic acids},
  year={2018}
}
Recent studies have shown the effect of microRNAs on HSC activation and transformation, which is essential for the pathogenesis of liver fibrosis. In our study, we explored the role of miR-185 in liver fibrosis. Plasma miR-185 was detected in hepatitis B virus-related liver fibrosis patients (S2/3, n = 10) by Illumina HiSeq sequencing, and healthy volunteers were selected (n = 8) as the control group. We found that the plasma miR-185 level in fibrosis patients was significantly downregulated… CONTINUE READING
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