miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma.

@article{Zhu2014miR182TC,
  title={miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma.},
  author={Hongling Zhu and Jin Fang and Jichen Zhang and Zefei Zhao and Lianyong Liu and Jingnan Wang and Qian Xi and Mingjun Gu},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={450 1},
  pages={
          857-62
        }
}
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44 Citations
Background Citations
17

44 Citations

miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6.
TLDR
Results suggested that miR-126 functions as a tumor-suppressive miRNA by targeting LRP6 regulating Wnt/β-catenin signaling pathway and represents a therapeutic target for PTC.
miR-182 promotes tumor growth and increases chemoresistance of human anaplastic thyroid cancer by targeting tripartite motif 8
TLDR
It is found that tripartite motif 8 (TRIM8) expression was downregulated in anaplastic thyroid cancer (ATC) tissues and cell lines and this downregulation was significantly correlated with the upregulation of miR-182 in human ATC tissues.
MicroRNA-221 promotes papillary thyroid carcinoma cell migration and invasion via targeting RECK and regulating epithelial–mesenchymal transition
TLDR
MiR- 221 may be involved in PTC cell invasion and metastasis by targeting RECK, indicating that the miR-221/RECK pathway could be studied further as a potential new diagnostic or prognostic biomarker for PTC.
LncRNA MEG3 enhances 131I sensitivity in thyroid carcinoma via sponging miR-182.
Epigenetic Silencing of SOX15 Is Controlled by miRNAs rather than Methylation in Papillary Thyroid Cancer
TLDR
The results indicate that SOX15 gene expression is associated with the pathogenesis of papillary thyroid carcinoma (PTC), and the epigenetic control of the SOx15 gene is regulated by miRNAs rather than by promoter methylation.
Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis
TLDR
The upstream regulators and the downstream target genes of miR-183-96-182 cluster are discussed, and the dysregulation and functional roles of this cluster in various tumor cells are highlighted.
Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p.
MiR-182 promotes cancer invasion by linking RET oncogene activated NF-ÎşB to loss of the HES1/Notch1 regulatory circuit
TLDR
A novel mechanism for MTC aggressiveness is demonstrated in which mutated RET/NF-ÎşB-driven expression of miR-182 impedes HES1 activation in a negative feedback loop and might open new possibilities to treat RET oncogene associated metastatic cancer.
CHL1 Is Expressed and Functions as a Malignancy Promoter in Glioma Cells
TLDR
Investigation of the effects of CHL1 on proliferation indexes and activation of Akt1 and Erk signaling by siRNA in U-87 MG human glioblastoma and human U251 and SHG-44 glioma cells confirmed for the first time thatCHL1 functions in promoting cell proliferation, metastasis and migration in human gl ioma cells both in vitro and in vivo.
Tissue microRNA-182 expression level and its potential prognostic value for papillary thyroid carcinoma.
TLDR
Overexpression of miR-182 is associated with aggressive clinicopathologic characteristics of PTC, and mi R-182 might be a novel prognostic molecular marker of P TC.
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