miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma.

@article{Zhu2014miR182TC,
  title={miR-182 targets CHL1 and controls tumor growth and invasion in papillary thyroid carcinoma.},
  author={Hongling Zhu and Jin Fang and Jichen Zhang and Zefei Zhao and Lianyong Liu and Jingnan Wang and Qian Xi and Mingjun Gu},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={450 1},
  pages={
          857-62
        }
}
miR-126 inhibits papillary thyroid carcinoma growth by targeting LRP6.
TLDR
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TLDR
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TLDR
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TLDR
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MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit
TLDR
A novel mechanism for MTC aggressiveness is demonstrated in which mutated RET/NF-κB-driven expression of miR-182 impedes HES1 activation in a negative feedback loop and might open new possibilities to treat RET oncogene associated metastatic cancer.
CHL1 Is Expressed and Functions as a Malignancy Promoter in Glioma Cells
TLDR
Investigation of the effects of CHL1 on proliferation indexes and activation of Akt1 and Erk signaling by siRNA in U-87 MG human glioblastoma and human U251 and SHG-44 glioma cells confirmed for the first time thatCHL1 functions in promoting cell proliferation, metastasis and migration in human gl ioma cells both in vitro and in vivo.
Tissue microRNA-182 expression level and its potential prognostic value for papillary thyroid carcinoma.
TLDR
Overexpression of miR-182 is associated with aggressive clinicopathologic characteristics of PTC, and mi R-182 might be a novel prognostic molecular marker of P TC.
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