miR-181b negatively regulates activation-induced cytidine deaminase in B cells

@article{Ybenes2008miR181bNR,
  title={miR-181b negatively regulates activation-induced cytidine deaminase in B cells},
  author={Virginia G de Y{\'e}benes and Laura Belver and David G. Pisano and Susana Gonz{\'a}lez and Aranzazu Villasante and Carlo M. Croce and Lin He and Almudena R Ramiro},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={2199 - 2206}
}
Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates. As a bystander effect, endogenous AID levels can also promote the generation of… CONTINUE READING