miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules.

@article{Bhushan2013miR181aPO,
  title={miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules.},
  author={Raghu Bhushan and Johannes Gr{\"u}nhagen and Jessica Becker and Peter N. Robinson and Cordula Ott and Petra I. Knaus},
  journal={The international journal of biochemistry & cell biology},
  year={2013},
  volume={45 3},
  pages={
          696-705
        }
}
Osteoblastic differentiation is controlled by complex interplay of several signaling pathways and associated key transcription factors, as well as by microRNAs (miRNAs). In our current study, we found miR-181a to be highly upregulated during BMP induced osteoblastic differentiation of C2C12 and MC3T3 cells. Overexpression of miR-181a led to upregulation of key markers of osteoblastic differentiation as well as enhanced ALP levels and Alizarin red staining, indicating the importance of this… CONTINUE READING
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