miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma.

@article{Lu2016miR15aIC,
  title={miR-15a induces cell apoptosis by targeting BCL2L2 and BCL2 in HPV-positive hypopharyngeal squamous cell carcinoma.},
  author={Wuhao Lu and Long Feng and Yan Zhang and Yun-yun Ma and Ping Li and Yuanyuan Wang and Yuwen Du and Xiaonan Chen and Shujun Wu and Guoqiang Zhao and Weihua Lou},
  journal={Oncology reports},
  year={2016},
  volume={36 4},
  pages={2169-76}
}
Aberrant expression of miR-15a was recently reported in several types of cancers; however, its role in HPV-positive hypopharyngeal squamous cell carcinoma (HSCC) remains obscure. In the present study, we investigated the mechanism by which miR-15a induces HPV-positive HSCC apoptosis. Synthetic miR-15a mimics were transfected into FaDu cells (HPV-negative), and the miR-15a inhibitor was transfected into HPV-positive HSCC cells. miR-15a expression was analyzed by RT-PCR, and BCL2L2 and BCL2 were… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 28 references

HER2 and HER3 in HPV+ and HPV- HNSCC--Response.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2016

Similar Papers

Loading similar papers…