miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors

  title={miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors},
  author={Marina Gonçalves Diniz and Carolina Cavali{\'e}ri Gomes and Wagner Castro and Andr{\'e} Luiz Sena Guimar{\~a}es and Alfredo Maur{\'i}cio Batista de Paula and Hope M. Amm and Chanchung Ren and Mary Macdougall and Ricardo Santiago Gomez},
  journal={Cellular Oncology},
A keratocystic odontogenic tumor (KCOT) is a benign destructive recurrent odontogenic cystic neoplasm. The microRNAs (miRNAs) miR-15a and miR-16-1 function as negative regulators of the anti-apoptotic gene BCL2 at the post-transcriptional level. Notably, high Bcl-2 immunoexpression is found in the epithelial lining of KCOTs, while the loss of Bcl-2 immunopositive cells is observed in marsupialized cysts. The purpose of this study was to investigate whether the transcription of miR-15a and miR… CONTINUE READING


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