miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.

@article{Sandhu2012miR155TH,
  title={miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model.},
  author={Sukhinder K. Sandhu and Stefano Volinia and Stefan Costinean and Marco Galasso and Reid Neinast and Ramasamy Santhanam and Mark R. Parthun and Danilo Perrotti and Guido Marcucci and Ramiro Garzon and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 49},
  pages={
          20047-52
        }
}
Multiple studies have established that microRNAs (miRNAs) are involved in the initiation and progression of cancer. Notably, miR-155 is one of the most overexpressed miRNAs in several solid and hematological malignancies. Ectopic miR-155 expression in mice B cells (Eμ-miR-155 transgenic mice) has been shown to induce pre-B-cell proliferation followed by high-grade lymphoma/leukemia. Loss of miR-155 in mice resulted in impaired immunity due to defective T-cell-mediated immune response. Here we… CONTINUE READING
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