miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism

@article{Sun2015miR155PT,
  title={miR-155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism},
  author={Xiaohui Sun and Xiaolin Geng and Jun Zhang and Hongxing Zhao and Ying Liu},
  journal={Molecular and Cellular Biochemistry},
  year={2015},
  volume={403},
  pages={139-147}
}
Osteosarcoma (OS) is a type of malignant tumor arising from soft-tissues of bone and displays poor prognosis in most cases. However, the molecular mechanism by which OS initiates and progresses is still not completely elucidated. miR-155 has been shown to be overexpressed in OS specimen and cell lines. Our study is intended to explore the role of miR-155 in OS etiology. The data confirmed that miR-155 abundance is higher in OS samples than non-cancerous bone tissue. Inhibition of miR-155… CONTINUE READING
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