miR-15 and miR-16 induce apoptosis by targeting BCL2.


Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.

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@article{Cimmino2005miR15AM, title={miR-15 and miR-16 induce apoptosis by targeting BCL2.}, author={Amelia Cimmino and George A. Calin and Muller Fabbri and Marilena V. Iorio and Manuela Ferracin and Masayoshi Shimizu and Sylwia E. Wojcik and Rami Ishaq Aqeilan and Simona Zupo and Mariella Dono and Laura Rassenti and Hansj{\"{u}rg Alder and Stefano Volinia and Chang-gong Liu and Thomas J. Kipps and Massimo Negrini and Carlo M. Croce}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2005}, volume={102 39}, pages={13944-9} }