miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2.

@article{Porstner2015miR148aPP,
  title={miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2.},
  author={Martina Porstner and Rebecca Winkelmann and Patrick Daum and Julia Schmid and Katharina Pracht and Joana C{\^o}rte-Real and Sandra Schreiber and Claudia Haftmann and Andreas Brandl and Mir-Farzin Mashreghi and K Gelse and Manuela Hauke and Ina Wirries and Markus Zwick and Edith A. Roth and Andreas Radbruch and J{\"u}rgen Wittmann and Hans-Martin J{\"a}ck},
  journal={European journal of immunology},
  year={2015},
  volume={45 4},
  pages={1206-15}
}
B cells undergo affinity maturation and class switch recombination of their immunoglobulin receptors during a germinal center (GC) reaction, before they differentiate into long-lived antibody-secreting plasma cells (PCs). Transcription factors such as Bach2 and Mitf are essential during this process, as they delay premature differentiation of GC B cells by repressing Blimp-1 and IRF4, two transcription factors required for terminal PC differentiation. Therefore, Bach2 and Mitf expression must… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 7 times over the past 90 days. VIEW TWEETS
19 Citations
44 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

miR - 148 a is upregulated by Twist 1 and Tbet and promotes the survival of T helper 1 cells by regulating the proapoptotic gene Bim

  • C. Haftmann, A. B. Stittrich, +4 authors K. Westendorf
  • Eur . J . Immunol .
  • 2015

Similar Papers

Loading similar papers…