miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.

  title={miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.},
  author={B. Li and X. Wang and I. Choi and Y. Wang and S. Liu and A. Pham and Heesung Moon and Drake J. Smith and D. Rao and M. Boldin and Lili Yang},
  journal={The Journal of clinical investigation},
  volume={127 10},
  • B. Li, X. Wang, +8 authors Lili Yang
  • Published 2017
  • Biology, Medicine
  • The Journal of clinical investigation
  • Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive Th17 cells and organ-specific autoimmunity remains largely unknown. Here, we have reported that miR-146a-deficient mice developed more severe experimental… CONTINUE READING
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