miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.

@article{Li2017miR146aMA,
  title={miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.},
  author={Bo Li and Xi Wang and In Young Choi and Yu-Chen Wang and Siyuan John Liu and Alexander T Pham and Heesung Moon and Drake John Smith and Dinesh S. Rao and Mark P Boldin and Lili Yang},
  journal={The Journal of clinical investigation},
  year={2017},
  volume={127 10},
  pages={
          3702-3716
        }
}
Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive Th17 cells and organ-specific autoimmunity remains largely unknown. Here, we have reported that miR-146a-deficient mice developed more severe experimental… CONTINUE READING
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