miR-146a Polymorphism Influences Levels of miR-146a, IRAK-1, and TRAF-6 in Young Patients with Coronary Artery Disease

@article{Ramkaran2013miR146aPI,
  title={miR-146a Polymorphism Influences Levels of miR-146a, IRAK-1, and TRAF-6 in Young Patients with Coronary Artery Disease},
  author={Prithiksha Ramkaran and Sajidah Khan and Alisa Phulukdaree and Devapregasan Moodley and Anil A Chuturgoon},
  journal={Cell Biochemistry and Biophysics},
  year={2013},
  volume={68},
  pages={259-266}
}
Modulation of nuclear factor KappaB (NF-κB) activation may play a role in regulating inflammatory conditions associated with coronary artery disease (CAD). MicroRNA-146a (miR-146a) primarily targets interleukin-1 receptor-associated kinase 1 (IRAK-1) and tumour necrosis factor receptor associated factor 6 (TRAF-6), which results in inhibition of NF-κB via the TLR pathway. This study investigated the influence of the miR-146a GC rs2910164 on miR-146a expression in young South African Indians… CONTINUE READING

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