miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.

@article{Larne2015miR145ST,
  title={miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.},
  author={Olivia Larne and Zandra Hagman and Hans G Lilja and Anders Bjartell and Anders Edsj{\"o} and Yvonne Ceder},
  journal={Carcinogenesis},
  year={2015},
  volume={36 8},
  pages={858-66}
}
Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression. The miR-145 levels, measured by quantitative reverse transcription-polymerase chain reaction, were found to inversely correlate with occurrence of metastases, survival and androgen deprivation… CONTINUE READING
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