miR-145, targeting high-mobility group A2, is a powerful predictor of patient outcome in ovarian carcinoma.

@article{Kim2015miR145TH,
  title={miR-145, targeting high-mobility group A2, is a powerful predictor of patient outcome in ovarian carcinoma.},
  author={Tae Hoen Kim and Ji-ye Song and Hyun Park and Ju-yeon Jeong and A Rom Kwon and Jin Hyung Heo and Haeyoun Kang and Gwangil Kim and Hee Jung An},
  journal={Cancer letters},
  year={2015},
  volume={356 2 Pt B},
  pages={937-45}
}
MicroRNA-145 (miR-145) expression is downregulated in several human cancers, but its clinical and functional relevance to ovarian carcinoma has not yet been elucidated. This study addressed the hypothesis that miR-145 serves as a prognostic biomarker and a tumor suppressor that regulates the expression of high-mobility group A2 (HMGA2) oncoprotein in ovarian cancer. Here, we found that low miR-145 expression and HMGA2 overexpression determined by qRT-PCR and immunohistochemistry significantly… CONTINUE READING

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A 2-Protein Signature Predicting Clinical Outcome in High-Grade Serous Ovarian Cancer.

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