miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2.

@article{Liu2012miR143ID,
  title={miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2.},
  author={Lipeng Liu and Xiaohua Yu and Xiaofang Guo and Z. G. Tian and Min Su and Yu Long and Chunxia Huang and Feng Zhou and Meiling Liu and Xinhua Wu and Xiaochun Wang},
  journal={Molecular medicine reports},
  year={2012},
  volume={5 3},
  pages={753-60}
}
microRNAs (miRNAs) are small non-coding RNA molecules of 21-24 nt that regulate the expression of other genes by transcriptional inhibition or translational repression. Multiple lines of evidence suggest that miRNAs play important roles in tumor development and progression. We identified 24 miRNAs markedly and aberrantly expressed in human cervical cancer. The most significantly deregulated was miR-143 as determined by miRNA microarray analysis. miR-143 was introduced into HeLa cells and it was… CONTINUE READING
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