miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1

  title={miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1},
  author={She Tian and Xingjun Guo and Chao Yu and Chengyi Sun and Jianxin Jiang},
The role of microRNA in the aberrant autophagy that occurs in pancreatic cancer remains controversial. Because hypoxia is known to induce autophagy, we screened for differentially expressed microRNAs using a miRNA microarray with pancreatic cancer cells cultured under normoxic and hypoxic conditions. We found that miR-138-5p was among the most downregulated miRNA in hypoxia-stimulated cells, and that overexpression of miR-138-5p substantially reduced expression of autophagy markers. In addition… CONTINUE READING
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