miR-135a modulates tendon stem/progenitor cell senescence via suppressing ROCK1.

@article{Chen2015miR135aMT,
  title={miR-135a modulates tendon stem/progenitor cell senescence via suppressing ROCK1.},
  author={Lei Chen and Guodong Wang and Jun-peng Liu and Hua-song Wang and Xi-ming Liu and Qing Wang and Xianhua Cai},
  journal={Bone},
  year={2015},
  volume={71},
  pages={210-6}
}
Tendon stem/progenitor cell (TSPC) senescence may lead to age-related tendon disorders and impair tendon regeneration and replacement capacity in humans. However, the mechanisms governing TSPC aging and degeneration remain obscure. Recently, it has been reported that Rho-associated coiled-coil protein kinase 1 (ROCK1) might be a key player in TSPC aging process. miRNAs are also involved in cellular senescence. In this study, whether miRNAs modulate senescence of TSPCs through targeting ROCK1… CONTINUE READING
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